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ea0065op3.4 | Metabolism and Obesity | SFEBES2019

Mice with a gain-of function Gα₁₁ mutation have autosomal dominant hypocalcaemia, but not impaired glucose metabolism

Gluck Anna , Lines Kate , Gorvin Caroline , Babinsky Valerie , Piret Sian , Sarbu Stefan , Stewart Michelle , Bentley Liz , Wells Sara , Cox Roger , Ecker Rupert , Ellinger Isabella , Hannan Fadil , Thakker Rajesh

The calcium-sensing-receptor (CaSR) is a G-protein-coupled receptor that plays a fundamental role in extracellular calcium homeostasis, but is also implicated in non-calcitropic disorders including colon cancer and asthma. In addition, CaSR is highly expressed in pancreatic islets where it has a role in insulin secretion. Patients with gain-of-function CaSR mutations, and mice (referred to as Nuf) with a gain-of-function CaSR mutation (Leu723Gln), develop autosomal dominant hy...

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Endocrine Abstracts

Mice with a gain-of function Gα₁₁ mutation have autosomal dominant hypocalcaemia, but not impaired glucose metabolism

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Endocrine Abstracts

Mice with a gain-of function Gα11 mutation have autosomal dominant hypocalcaemia, but not impaired glucose metabolism

BiosciAbstracts

Mice with a gain-of function Gα₁₁ mutation have autosomal dominant hypocalcaemia, but not impaired glucose metabolism